Anti-Human CD49d Monoclonal Antibody(PE/Cyanine7 Conjugated)

Product name:	Anti-Human CD49d Monoclonal Antibody(PE/Cyanine7 Conjugated)
Catalog:	DL21763F
Synonyms :	Integrin alpha-4,CD49 antigen-like family member D,Integrin alpha-IV,VLA-4 subunit alpha,CD49d,ITGA4
Reactivity:	Human
Applications:	FCM
Size:	20 Tests/50 Tests/100 Tests/200 Tests
Host:	Mouse
Clonality:
Conjugation:
Background:	CD49d is a 150 kD ?? integrin chain known as ??4 integrin or VLA-4 ?? chain. It forms a heterodimer with either integrin ??1 (??4??1, VLA-4) or ??7 (??4??7). CD49d is expressed broadly on T lymphocytes, B lymphocytes, monocytes, thymocytes, eosinophils, basophils, mast cells, NK cells, dendritic cells, and some non-hematopoietic cells, but not on normal red blood cells, platelets or neutrophils. VLA-4 binds to VCAM-1 (CD106) and fibronectin. ??4??7 is the receptor for VCAM-1 and MAdCAM-1. CD49d participates in mononuclear cell trafficking to endothelial sites of inflammation and has roles in cell-cell interactions and cell adhesion to extracellular matrices. CD49d is involved in lymphocyte migration, T cell activation, and hematopoietic stem cell differentiation. CD49d is a marker to isolate pure populations of Treg cells due to its absence on Foxp3+ cells.
Concentration:
Buffer:	PBS with 0.05% Proclin300, 1% BSA
Gene_ID:	3676
Clone_NO:	9F10
SwissProt:	P13612
Isotype:	Mouse IgG1, ?
Storage:	Store at 2~8?? and protected from prolonged exposure to light. Do not freeze.

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DL21763F